HistaGest‑DAO™ provides supplemental diamine oxidase(DAO), the enzyme responsible for breaking down food‑derived histamine.

Each tablet provides 20,000 histamine‑degrading units of DAO from porcinekidney extract to promote the breakdown of dietaryhistamines.* HistaGest‑DAO™ is formulated withgastro‑resistant, coated tablets with delayed‑releasetechnology that allows the DAO enzyme to reach thesmall intestine where it performs its action.Histamine is a vital compound synthesized from the essential amino acid histidine. Histamine is produced in the body and resides in various tissues, including the liver, lungs, intestine, heart, pancreas, and various other organs.Histamine is primarily stored and released by certain immune cells, but also by a variety of other cells, in response to an injury or in the presence of foreign substances. It is also present in all foods in the diet in various degrees. Common histamine‑rich food sources include fermented foods such as sauerkraut, vinegar, yogurt, alcoholic beverages, fish, cured meats and cheese,and certain fruits and vegetables (e.g., ripe bananas,citrus, spinach, and tomatoes).DAO is present in the gut and its main function is to metabolize ingested dietary histamines. Reduced DAO activity may result in higher levels of histamine being absorbed through the small intestine and accumulating in the blood.